Squishies – The Latest Craze Sweeping Middle Schools and Beyond

Kids are natural born collectors. They also love fads. Enter: the Squishy. These Japanese imports are the newest craze and are causing quite a stir. Not only are they hard to find, as they are not sold in your average store, most adults have never heard of them.

Today we will answer all of the common questions we receive about squishies. What are they? Squishies are soft “bread like” mascots, shaped as either a type of baked good, a character, or a combination of the two. They are the newest version of the stress ball, yet softer and more “kawaii” (the Japanese word for “cute”). Squishies are usually scented, cake or bread being the most common choice. Typically, squishies are attached to a cell phone strap or a lanyard.

Why do kids love them? Well, of course they are cute. Squishies are tactile and fun for kids to “squish” over and over, hence the name. Add in the sweet scent and you have a multiple sensory toy that can be quite irresistible.

Where did this fad come from? Like many great fads, this is another one of those fun and wacky imports from Japan. Japanese teens (and adults!) love to decorate their cell phones with fake treats, fruits and gems. This is called deco-den. You have probably seen someone with a Hello Kitty cell phone “blinged out” in this manner. In addition to making their cell phone covers as kawaii as can be, they also love to hang cute or funny straps from them. Cell phone straps are a huge trend in Japan, and have been for several years.

In trying to pin down how kids in the US have become obsessed with squishies, we seem to have narrowed it down one powerful source: YouTube. Search the word “squishies” in YouTube and you will find hundreds upon hundreds of videos all about them. On YouTube, kids, and even adults, trade squishies, show off their squishy collection and even attempt to make home made squishies. Two things are quite clear in watching these videos. A. these kids are absolutely obsessed with squishies. B. they want a lot of them, and the more “rare” the better.

Where can you find rare squishies, or even squishies in general? You will find the best variety in Japan. Of course, most parents are not willing to travel around the world for a five dollar trinket. Another place they seem to show up from time to time is in Japan Towns and even China Towns that exist in a handful of cities across the country. The easiest place to find them is right at your finger tips.

Using Large Aperture Settings – Digital Photography Tips

If you want your photo to be as sharp as possible then you are going to need to learn some good information about how to use the aperture settings in your camera. Improper use of this in your camera can make for photos that are not as great as they possibly can be.

There are many different measurements in photography. The measurements are measurements mostly of light and the amount of time that the photo is exposed. The aperture is something that you really should try to understand. The aperture what controls the amount of light that is let into the camera.

In photography, light is critically important and controlling it correctly will make your photos much better. The aperture is measured in F-stops. There are different values ​​of aperture that can be large and small. A larger aperture will let more light into the camera for exposure. Because more light is let in you can expose the image faster and then use a faster shutter speed. This can really be useful when you are taking pictures of fast movement and need a fast shutter speed. Also, using a fast shutter speed will ensure you do not get the camera shake effect from your hands.

Another great tool that you can do with using a large F-Stop in your aperture is that it can make your image sharper. What the larger aperture will do is make the depth of field be much smaller. This will make whatever is out of the small depth of field be out of focus. This can make the background be very out of focus and the depth of field area will be in focus. Even if you have the object in focus slightly out of focus, since it is the only area of ​​the image that is in focus it'll look much more focused. Of course, you always want to make sure your photo is as focused as possible.

Using a smaller f-stop for your aperture will require the opposite of what the larger aperture does. Because the smaller aperture will make less light to expose the image, it will make you need to use a slower shutter speed to expose more light. What happens with a smaller opening as an aperture is that the light that is let in will be much more directed and then will make for much sharper images everywhere. A small aperture can make for very sharp images through the entire z axis. This will make the background in focus and the foreground in focus. This is great when taking landscape photos or photos of large fields like football fields where you want the entire picture in focus.

Credit Repair Companies – Find Credit Experts and Certified FICO Professionals – Improve Your Score

Late payment of credit bills or defaulting from payment can seriously affect one's credit scores. It affects a person's credit in securing a loan or a credit card in the future. This can cause dangerous repercussions and leave the person dependent on others for money. It is always advisable to keep your credit score clean.

But sometimes even the most organized person may end up with a bad credit score. Luckily, the law provides a chance to help the person out the situation. This is where the credit repair companies come into picture.

ROLE OF CREDIT REPAIR COMPANIES

Credit repair companies have a primary goal to 'improve the client's credit score'. They offer legal credit solutions to help improve their client's credit score. They study the report of the client to look for any inconsistencies. Once having identified disputable items on the report, they take it up with the creditor to challenge the report. If the inconsistencies can not be verified, then the company helps you file for damages. Some companies also offer credit management services to teach the client how to maintain a good credit score.

BEWARE OF SCAM COMPANIES

A person must always be aware of the service they choose. There are companies that scam desperate people, who are badly in need of help. There are other companies that use illegal means like identity theft to make it look like there is an improvement in the credit score. It is illegal and felony to do so and if discovered, the person may face jail time.

INDICATORS OF A GOOD COMPANY

It is very easy to tell a good company from a bad one. Here are a few indicators that it is a scam.

  • The company requests for payment upfront. Any citizen is legally entitled to pay the credit repair company only after the case is settled.
  • If the company promises to erase the credit record, it is clearly a scam. It is impossible to delete it. One can only improve the credit score.
  • When the company requests the client to create a new credit identity using Employer Identification Number (EIN) instead of the social security number, it is undocumentedly a scam company.
  • If the company requests a person to file all the items in the record as false irreparable of the validity, then it is a scam.

FIND THE BEST CREDIT REPAIR COMPANY

Self acclaimed Credit pros, may not be professionals after all, although as an industry they are one of the topought after services in the country. Understandably, without money or credit life's dreams are halted in a hurry. Be sure to look for a team of certified FICO professionals, who offer professional and legal credit solutions and help can anyone with a bad credit score. Check reviews and see if the company has a record of being successful and customer friendly in all their cases. The clients' testimonials are a proof for the good work they can do.

WHAT SETS A CREDIT PROFESSIONAL APART FROM THE REST?

  • Payment is accepted only after the client's requirements are met and payment plans are also available.
  • The client can cancel their service at any time they see fit.
  • They offer life-time support for the cases they handle.
  • Team of FICO certified professional experts guarantee success and do not oversell.

If ever you have a credit record problem, you should be able to seek a free consultation from the credit experts. With upfront information and a proven track record, you can have confidence that you have found the right credit repair company to help you.

Preformulation and Formulation Development

Optimizing Conformational Stability and Biological ActivityMaintenance of the native three dimensional conformation is critical for the long term stability and biological activity of biotherapeutics. Biophysical characterization techniques such as circular dichroism, differential scanning calorimetry, FTIR, dynamic light scattering, and fluorescence spectroscopy provide a mechanism to assess the conformational and thermodynamic stability of proteins under a range of formulation conditions. These tools allow development scientists to differentiate various various buffer, pH, ionic strength, and excipient conditions, and identify the conditions that confer the optimum environment for the therapeutic protein.

Utilizing Advanced Statistical Design for Preformulation Development Preformulation development includes statistical design of experiments, allowing simultaneous evaluation of multiple factors and evaluation of interactions between factors. It is crucial to use advanced biophysical characterization techniques to evaluate the conformational stability of large molecules in addition to traditional methods for evaluation of chemical stability.

A large molecule preformulation development program typically includes the following activities:
Evaluate the effect of pH, buffer type, and ionic strength on solubility.
Evaluate the effect of various excipients on improving solubility if necessary.
Evaluate effects of pH, buffer type, and excipients on conformational stability.
Evaluate the effect of pH, buffers, excipients and ionic strength on physical and chemical stability.
Utilize a statistical design approach to identify the optimal conditions for structural, physical and chemical stability.
Perform forced degradation to elucidate product degradation pathways and to demonstrate the stability-indicating capacity of the analytical methods.
Forced degradation studies typically include restricted oxidation, deamidation, aggregation (via agitation), and / or acid / base hydrolysis.
Evaluation of heat stress, photo stress, and freeze thaw are also performed.

Looking for information on Analytical Development and other related resources?

Formulation Development for Numerous Dosage FormsFormulation development includes dosage forms for parenteral, oral topical and inhalation administration, including liquids, gels, suspensions, emulsions and lyophilized powders. Formulation scientists are highly skilled in the development of the dosage forms most relevant to biotherapeutics, with particular expertise in lyophilization and development of stable liquid formulations for proteins. High concentration antibody formulation development for subcutaneous administration requires particular emphasis on viscosity and tonicity. Lyophilization cycle development is performed in the context of the unique thermodynamic properties of the API to deliver an efficient, scalable, transferable process resulting in optimum product stability and reconfiguration characteristics. Formulation development capabilities also include:

Effect of excipients on solubility, tonicity, and viscosity Evaluation of antioxidant and conservative compatibility Container-closure compatibility Long term and accelerated stability studies.

Advantages of Formulation Development Approach. This outlined approach to preformulation and formulation development result in significant savings to the client by eliminating the variables associated with suboptimal formulations. Preclinical development efforts in PK, PD, ADME and toxicology occur with confidence that additional uncontrollable variables from unstable formulations are not introduced into the study. This benefit extends far into clinical trials as well, where assessment of toxicity, dosage levels and efficiency are substantially influenced by an optimal formulation that preserves the three dimensional conformation of the therapeutic protein. By eliminating uncontrolled stability variables, the focus is placed solely on the therapeutic performance and clinical outcome.